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KMID : 0390020080180020189
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Pediatric Allergy and Respiratory Disease
2008 Volume.18 No. 2 p.189 ~ p.193
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Isolation of Enterovirus Type 71 in a 3-year-old Boy Suffering from Toxic Epidermal Necrolysis
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Han Sang-Myung
Park Joon-Soo
Han Sang-Ho
Song Jun-Hwan
Lee Yoon-Hee
Park Kwi-Sung
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Abstract
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Toxic epidermal necrolysis (TEN) is an exfoliative disease of skin and characterized by flaccid bullae and spreading erythema so that the skin has the appearance of being scalded. It results primarily from a toxic reaction to various drugs, but occasionally occurs as a result of infection, neoplastic conditions, or other exposure. Enterovirus 71 (EV 71), the most recently described serotype of the genus Enterovirus (family Picornaviridae), causes a variety of diseases, including aseptic meningitis, encephalitis, poliomyelitis-like paralysis, hand-foot-mouth disease, gastroenteritis, fever and rash. A 3-year-old boy presented at the Department of Pediatrics, Soonchunhyang University Cheonan Hospital due to TEN. There were no definite causes such as drug toxicity, Graft-Versus-Host disease (GVHD) and infection. However, we could have isolated EV 71 from the patient’s stool. Until now, there have been no reports showing the relationship between EV 71 and TEN, we report here in a case of TEN-associated with EV 71. Further evaluation is needed to study the relationship of TEN with EV 71.
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KEYWORD
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Toxic Epidermal Necrolysis, Enterovirus 71, Child
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